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The allergic march – prevalence of allergic manifestations by age1-2

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CMA is most common in early childhood, and estimates of prevalence in infants vary from 2% to 7.5%.3-4

  • This figure decreases with age, to around 0.1–0.5% in adulthood.4
  • However, self-reports of CMA are much more common than confirmed CMA.5 Some studies have found that the parent-reported prevalence of CMA may be up to 17.5% for preschool children.5

Recovery from CMA and the allergic march

Most infants grow out of CMA by 3 years of age.6

However, there remains a strong tendency for infants who have had CMA to develop additional atopic symptoms, such as asthma, hay fever and eczema later in life – the so-called "allergic march".4

Nutramigen is the only infant formula for cow’s milk allergy which has evidence of oral tolerance to cow’s milk.7 This has many benefits for the quality of life of the infant and their family, and for your budget.

Show references
  1. Halken S. Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatr Allergy Immunol 2004;15 Suppl 16:4-32.

  2. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol 2003;112:S118-S127.

  3. Du Toit G, Meyer R, Shah N et al. Identifying and managing cow's milk protein allergy. Arch Dis Child Educ Pract Ed 2010;95:134-44.

  4. Crittenden RG, Bennett LE. Cow's milk allergy: a complex disorder. J Am Coll Nutr 2005;24:582S-91S.

  5. Fiocchi A, Brozek J, Schunemann H et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. World Allergy Organization Journal 2010;3:57-161.

  6. Host A, Halken S, Jacobsen HP et al. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002;13 Suppl 15:23-8.

  7. Canani R et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy: A randomized trial. Jour All Clin Immunol 2012; 129:580–582.