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This website is intended for healthcare professionals and contains information about Mead Johnson Nutrition special infant formulas.

Important Notice: Breast feeding provides the best nutrition for babies. Mead Johnson special formulas are intended for bottle-fed infants and are Food for Special Medical Purposes (FSMPs) and must be used under medical supervision.

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Introducing Nutramigen 1, 2 & 3 with LGG®

Nutramigen 1, 2 & 3 with LGG® are foods for special medical purposes and should only be used under the supervision of a healthcare professional.

  • Nutramigen 1, 2 & 3 with LGG are extensively hydrolysed casein-based formulas (eHCFs) combined with Lactobacillus rhamnosus GG (trademark LGG®), a unique probiotic strain
  • For the dietary management of infants and children with cow’s milk allergy (CMA)
Nutramigen 1 with LGG®Nutramigen 2 with LGG®Nutramigen 3 with LGG*
400g 400g 400g
PIP code: 019-8861 PIP code: 298-7766 PIP code: 406-4325
For infants aged 0-6 months For infants aged 6 months onwards as part of a varied diet For children from 1 year onwards as part of a varied diet

Short term: symptom relief

  • Proven to have an average efficacy of 99%1†
  • Faster resolution of CMA symptoms vs Nutramigen without LGG2,3

Medium term: oral tolerance acquisition

  • The only eHF clinically proven to accelerate the return to milk4‡
  • 8 out of 10 infants get back to milk after 12 months of use5

Long term: sustained results and allergic manifestation reduction

  • The accelerated return to milk was shown to be sustained during a period of 3 years of dietary intervention6
  • ~50% reduction in the incidence of ≥1 other allergic manifestation compared to Nutramigen alone during a period of 3 years6

 

Nutramigen with LGG® is not recommended for premature and immunocompromised infants unless directed and supervised by a healthcare professional.

†Studied before the addition of LGG®. Calculated using data on allergic reactions after oral food challenge with an eHF from table 3 of Dupont et al. 2012, as judged by the Committee on Nutrition of the French Society of Paediatrics.

Versus an eHCF without LGG® or formulas based on rice hydrolysate, soy or amino acids. ‘Return to milk’ or ‘oral tolerance’ means the normal physiological process in which the daily diet plays a role.

What is LGG®?

LGG® is a probiotic isolated from the intestinal tract of healthy humans. LGG® has pili — hair-like appendages found on the probiotic that enable effective colonisation of the gut.7

Why add LGG® to Nutramigen?

Clinical evidence demonstrates that the combination of Nutramigen with LGG® accelerates the return to milk and reduces the incidence of other allergic manifestations‡ in infants with cow’s milk allergy (CMA)8,9

Well-established efficacy

  • The results of studies demonstrating the efficacy of LGG® cannot be extrapolated to other probiotics or other Lactobacillus strains10
  • Nutramigen with LGG® is available in many EU countries and beyond, and is used for the dietary management of CMA

 

Versus an eHCF without LGG® or formulas based on rice hydrolysate, soy or amino acids.
Compared to Nutramigen alone during a period of 3 years.

Instructions for preparation and use

Please note the preparation instructions of Nutramigen with LGG® (which has replaced Nutramigen LIPIL) have been updated since the preparation instructions for Nutramigen LIPIL in order to preserve the LGG®.

Nutramigen 1, 2 & 3 with LGG® are foods for special medical purposes and should only be used under the supervision of a healthcare professional.

instruction_01.png

Wash hands and clean preparation area thoroughly

- Clean bottles, teats, caps and utensils in water (at least 10 minutes at a rolling boil)

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Boil fresh water. (Do not use softened water)

- As soon as possible, pour desired amount of boiled water into clean bottle and cap

- Allow the water in the sealed bottle to cool down to room temperature

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On a clean surface, add the required number of level scoops of powder (see feeding guide provided below)

- Store dry scoop in the tin

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Cap the bottle, roll and shake well until powder dissolves completely

- Check temperature by dropping fluid on the inside of your wrist.

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Once prepared, formula can spoil quickly. Feed immediately after preparation or cover and store in a refrigerator at 2-4°C for no longer than a total of 24 hours

- Do not freeze prepared formula and do not use if unrefrigerated for more than a total of 2 hours

- Use formula that has been in contact with baby's mouth within 1 hour and do not refrigerate. Throw away any prepared formula left in bottle and clean utensils

- Do not heat feeds in a microwave

As probiotics are inactivated by hot water, the reconstitution of a feed containing probiotics falls outside of current WHO recommendations. The BDA recommends that when healthcare facilities are able to make individual fresh feeds with foods for special medical purposes that contain probiotics for immediate consumption, these should be reconstituted by adhering to a strict safe preparation technique.11

Feeding guides

Use the charts below as a guide for the correct amounts of cooled boiled water and powder to use.

Nutramigen 1 with LGG®

AgeApprox. weight (kg/Ibs)Number of bottles/24 hWater
(ml/fl.oz)
Scoops
0-2 weeks 690 / 33
2-4 weeks 3.5-4 kg / 7 ½-8 ½ 5-6 120 / 4 4
1-2 months 4-5 kg / 8 ½-11 5 150 / 5 5
2-4 months 5-6.5 kg / 11-14 4-5 180 / 6 6
>4 months >6.5 kg / >14 4 210 / 7 7

Only use the scoop provided in the product tin. Do not press or pack powder into scoop, level off with the back of a clean, dry knife. Add 1 level scoop (4.5 g) to each 30 ml of water.

Nutramigen 2 with LGG®

AgeBottles / 24hWater
(ml/fl.oz)
Scoops
6-12 months 2-3 210/7 7
> 1 year 3 210/7 7

Only use the scoop provided in the product tin. Do not press or pack powder into scoop, level off with the back of a clean, dry knife. Add 1 level scoop (4.7 g) to each 30 ml of water.

Nutramigen 3 with LGG®

AgeBottles or cups / 24hWaterScoopsAverage ml of feeding
≥ 1 year 2 120 7 230

Only use the scoop provided in the product can. Do not press or pack powder into scoop, level off with the back of a clean, dry knife. Add 1 level scoop (4.5g) to each 30ml of water.

Nutramigen with LGG® is not recommended for premature and immunocompromised infants unless directed and supervised by a healthcare professional.

Nutramigen 1, 2 & 3 with LGG® are foods for special medical purposes and should only be used under the supervision of a healthcare professional. Nutramigen with LGG® is not recommended for premature and immunocompromised infants unless directed and supervised by a healthcare professional.

Our Mead Johnson Nutrition range of infant formulas are nutritionally tailored for each age group and indication. Review the ingredient information below.


Nutramigen 1 with LGG®

Glucose syrup, vegetable oils (palm olein, coconut, soya, high oleic sunflower), extensively hydrolysed casein (from milk), modified corn starch, calcium phosphate, calcium citrate, potassium citrate, potassium chloride, single cell oils (ARA from Mortierella alpina and DHA from Crypthecodinium cohnii), sodium citrate, L-cystine, sodium L-ascorbate, choline chloride, inositol, L-tyrosine, magnesium oxide, L-tryptophan, ferrous sulphate, taurine, Lactobacillus rhamnosus GG culture (0.034%), L-carnitine, DL-alpha tocopheryl acetate, zinc sulphate, ascorbic acid, nicotinamide, calcium pantothenate, cupric sulphate, retinyl palmitate, manganese sulphate, riboflavin, thiamine hydrochloride, cholecalciferol, pyridoxine hydrochloride, sodium iodide, folic acid, sodium molybdate, phytomenadione, chromic chloride, D-biotin, sodium selenite, cyanocobalamin.
May not be suitable for some cultural groups.

Nutramigen 2 with LGG® 

Glucose syrup, vegetable oils (palm olein, coconut, soya, high oleic sunflower), extensively hydrolysed casein (from milk), fructose, modified corn starch, calcium citrate, calcium phosphate, potassium phosphate, magnesium phosphate, potassium citrate, potassium chloride, single cell oils (ARA from Mortierella alpina and DHA from Crypthecodinium cohnii), L-cystine, choline chloride, sodium L-ascorbate, L-tyrosine, inositol, L-tryptophan, ferrous sulphate, Lactobacillus rhamnosus GG culture (0.034%), taurine, zinc sulphate, L-carnitine, nicotinamide, DL-alpha tocopheryl acetate, ascorbyl palmitate, ascorbic acid, calcium pantothenate, cupric sulphate, pyridoxine hydrochloride, retinyl palmitate, riboflavin, thiamin hydrochloride, cholecalciferol, manganese sulphate, chromic chloride, sodium iodide, folic acid, sodium molybdate, phytomenadione, sodium selenite, D-biotin, cyanocobalamin.
May not be suitable for some cultural groups.

Nutramigen 3 with LGG® 

Glucose syrup, vegetable oils (palm olein, coconut, soya, high oleic sunflower), extensively hydrolysed casein (from milk), fructose, modified corn starch, calcium citrate, potassium citrate, calcium phosphate, single cell oils (ARA from Mortierella alpina and DHA from Schizochytrium sp), magnesium phosphate, potassium chloride, calcium carbonate, choline chloride, sodium citrate, sodium L-ascorbate, ferrous sulphate, flavourings (vanilla), Lactobacillus rhamnosus GG bacteria culture (0.02%), zinc sulphate, L-carnitine, nicotinamide, DL-alpha tocopheryl acetate, ascorbyl palmitate, ascorbic acid, calcium pantothenate, cupric sulphate, riboflavin, retinyl palmitate, pyridoxine hydrochloride, thiamine hydrochloride, manganese sulphate, folic acid, sodium iodide, chromic chloride, sodium molybdate, sodium selenite, phytomenadione, D-biotin, cholecalciferol, cyanocobalamin.

Show references
  1. Dupont C et al. Brit J Nutr 2012;107:325–38
  2. Baldassarre ME et al. J Pediatr 2010;156:397–401.
  3. Nermes M et al. Clin Exp Allergy 2011;41:370–377.
  4. Canani RB et al. J Pediatr 2013;163:771–777.
  5. Canani RB et al. J Allergy Clin Immunol 2012;129:580–2.
  6. Canani RB et al. J Allergy Clin Immunol 2017;139:1906-1913.
  7. Kankainen M et al. Proc Natl Acad Sci USA 2009;106:17193–17198.
  8. Majamaa MD & Isolauri EJ. Allergy Clin Immunol 1997;99(2):179–185.
  9. Canani RB et al. J Pediatr 2013;163(3):771–777.
  10. Canani RB et al. J Allergy Clin Immunol 2017;139:1906-1913.
  11. Cosenza L et al. Benef Microbes 2015;6:225–232.
  12. BDA. Guidelines for the Preparation and Handling of Expressed and Donor Breast Milk and Special Feeds for Infants and Children in Neonatal and Paediatric Health Care Settings. 2016